Regional haemodynamic responses to the cannabinoid agonist, WIN 55212-2, in conscious, normotensive rats, and in hypertensive, transgenic rats
نویسندگان
چکیده
منابع مشابه
Changes in motor and learning behaviors of rats prenatally exposed to WIN 55212-2, a cannabinoid receptor agonist
Abstract* Introduction: Cannabis consumption during pregnancy may affect fetal growth, motor performance, memory and cognitive functions. Methods: Primiparous pregnant Wistar rats were randomly assigned to 4 treatment groups (6 rats per group) consisting of control and sham groups as well as 2 groups treated with Win. Win treated groups received daily s.c. injections of 0.5 or 1 mg/kg WIN ...
متن کاملChanges in motor and learning behaviors of rats prenatally exposed to WIN 55212-2, a cannabinoid receptor agonist
Introduction: Cannabis consumption during pregnancy may affect fetal growth, motor performance, memory and cognitive functions. Methods: Primiparous pregnant Wistar rats were randomly assigned to 4 treatment groups (6 rats per group) consisting of control and sham groups as well as 2 groups treated with Win. Win treated groups received daily s.c. injections of 0.5 or 1 mg/kg WIN suspended in 1%...
متن کاملBlood Pressure Responses of Conscious Normotensive and Spontaneously Hypertensive Rats
In conscious spontaneously hypertensive rats, intracerebroTentricular injection of captopril (2 rag/kg) resulted in a rapid hypotenshe response that lasted several hours. The same dose given by Intracerebroventricular injection had no significant effect on blood pressure (BP) of normotensive Wistar-Kyoto (WK) rats over 7 hours. There was no significant change in BP of conscious spontaneously hy...
متن کاملThe effect of spinally administered WIN 55,212-2, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats
Objective(s):Diabetic neuropathy (DN) is a common complication of diabetes that leads to allodynia, impaired nerve conduction, and progressive sensory loss. The aim of this study was to observe the effect of a high-affinity cannabinoid receptors agonist, WIN 55,212-2, on thermal hyperalgesia, nerve conduction velocity and sciatic nerve histopathology in diabetic rats. Materials and Methods: Di...
متن کاملArterial chemoreflex in conscious normotensive and hypertensive adult rats.
Evidence from human and animal studies suggests that the arterial chemoreflex may be exaggerated in essential hypertension. In the present study, cardiorespiratory responses to peripheral chemoreceptor stimulation were compared in conscious unrestrained spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats (13-14 wk old). Chemoreceptors were stimulated...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2001
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0704100